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| Nomenclature |
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Symbol:
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Tg(Prnp-App/APPswe)E1-2Dbo
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Name:
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transgene insertion E1-2, David R Borchelt
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MGI ID: |
MGI:3696473 |
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Synonyms: |
E1-2 line, line E1-2, Mo/Hu APPswe, Mo/Hu APPswe line E1-2 |
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Transgene:
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Tg(Prnp-App/APPswe)E1-2Dbo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x C3H/HeJ)F2
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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This transgene expresses a modified mouse amyloid precursor protein cDNA encoding the 695-amino acid isoform with a "humanized" Abeta domain amino acid sequence that includes the familial Alzheimer disease- (FAD-) associated Swedish double mutation (Lys595Asn and Met596Leu). The cDNA was inserted into an expression cassette containing the promoter, 5' intronic and 3' untranslated region sequences of the mouse prion protein gene. (J:80782) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
Disease Model |
Tg(Prnp-App/APPswe)E1-2Dbo/0 |
B6.C3-Tg(Prnp-App/APPswe)E1-2Dbo |
nervous system behavior/neurological other phenotype 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Notes |
Three transgenic lines were generated and designated by the authors lines Q2-2, E1-2 and C3-3 (Tg(APP695)3Dbo).
They were estimated, on the basis of Southern blot analysis, to carry 3-10 copies of the transgene.
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| References |
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Original: |
J:80782
Borchelt DR et al.,
"A vector for expressing foreign genes in the brains and hearts of transgenic mice."
Genet Anal 1996 Dec;13(6):159-63
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All: |
2 reference(s)
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