Tg(Prnp-App/APPswe)E1-2Dbo Other Genome Feature Detail
Symbol
Name
ID
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Tg(Prnp-App/APPswe)E1-2Dbo
transgene insertion E1-2, David R Borchelt
MGI:3696469
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Nomenclature History
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Synonyms
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E1-2 line, line E1-2, Mo/Hu APPswe, Mo/Hu APPswe line E1-2
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Genetic Map
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Alleles
and
phenotypes
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All alleles(1) :
Transgenic(1)
| Mice express ~3-fold higher levels of the Swedish variant of human APP than normal levels of mouse App. At levels sufficient to induce plaque formation (age 24-26 months), no abnormalities in neural circuits involved in spatial or nonspatial memeory are observed. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
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References
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(Earliest)
J:80782
Borchelt DR et al.,
"A vector for expressing foreign genes in the brains and hearts of transgenic mice."
Genet Anal 1996 Dec;13(6):159-63
(Latest)
J:109847
Savonenko AV et al.,
"Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE."
Neurobiol Dis 2003 Apr;12(3):194-211
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All references(2)
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