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| Nomenclature |
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Symbol:
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Il3ram1
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Name:
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interleukin 3 receptor, alpha chain;
mutation 1
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MGI ID: |
MGI:3652833 |
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Synonyms: |
Il3raA/J, Il3ran |
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Gene:
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Il3ra
Location:
Chr14:15179009-15188004 bp, + strand
Genetic Position: Chr14,
1.5 cM
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Mutation
origin |
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Intragenic deletion |
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Sequence analysis revealed A/J mice lack the sequence corresponding to exon 8, which encodes 10 amino acid residues in the extracellular domain. Aberrant splicing was due to a 5 base pair deletion at the branch point in intron 7. (J:23971) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:23971
Ichihara M et al.,
"Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene."
EMBO J 1995 Mar 1;14(5):939-50
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All: |
3 reference(s)
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