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| Nomenclature |
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Symbol:
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Disc1del
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Name:
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disrupted in schizophrenia 1;
deletion
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MGI ID: |
MGI:3623217 |
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Synonyms: |
Disc1129S6 |
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Gene:
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Disc1
Location:
Chr8:127578095-127785758 bp, + strand
Genetic Position: Chr8,
69.6 cM
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Mutation
origin |
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Strain of Origin:
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various
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Intragenic deletion |
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A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. (J:107244) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
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Disc1del/Disc1del |
B6.129S6-Disc1del |
behavior/neurological |
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Notes |
This deletion appears in multiple strains of the 129 superfamily. See J:111837 for details.
This deletion has further been identified in the following strains: 101/RI, BTBR T+ tf/J and LP/J J:118317
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| References |
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Original: |
J:107244
Koike H et al.,
"Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice."
Proc Natl Acad Sci U S A 2006 Mar 7;103(10):3693-7
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All: |
3 reference(s)
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