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| Nomenclature |
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QTL variant:
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Ccs1C57BL/6Ha
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Name:
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colon cancer susceptibility 1;
C57BL/6Ha
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MGI ID: |
MGI:3618099 |
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QTL:
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Ccs1
Location:
unknown
Genetic Position: Chr12,
cM position of peak correlated region/allele: 38.0 cM
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Variant
origin |
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Strain of Specimen:
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C57BL/6Ha
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Variant
description |
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Allele
Type: |
QTL |
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Mutation: |
Undefined |
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This allele confers resistance to colon tumors compared to ICR/Ha. (J:19675) |
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  ot1
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Ccs1C57BL/6Ha/? |
involves: C57BL/6Ha * ICR/Ha |
tumorigenesis |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markers (J:19675)
A genome wide search was made in an attempt to find microsatellite markers linked to Ccs1 (colon cancer susceptibility 1) in 122 progeny derived from a (ICR/Ha x C57BL/6Ha)F1 x C57BL/6Ha backcross. ICR/Ha is susceptible and C57BL/6Ha resistant to DMH induced colon tumors. 177 polymorphic markers spaced 5 cM - 30 cM apart were used for the genome scan. Chi square tests indicated linkage with all tested Chromosome 12 markers and the association of Ccs1 with D12Mit6 (45 cM) showed the greatest significance (P < 0.001)> A LOD score of 2.9 between Ccs1 and D12Mit6 was also indicated. ICR/Ha-derived alleles at Ccs1 are associated with colon tumor susceptibility whereas C57BL/6Ha-derived alleles are associated with colon tumor resistance. A potential candidate gene mappingnear Ccs1 is Tgfb3 (41 cM). A linkage map of Chromosome 12 based on the backcross analysis indicated the following order: D12Nds11 - 14.5 cM - D12Mit2 - 12.9 cM - D12Mit4 - D12Mit5 - 3.2 cM - D12Mit51 - D12Rfj1 -3.2 cM - D12Mit6 - Ccs1 - 3.2 cM - D12Mit30 - 4.8 - cM - D12Mit7 - 9.7 cM - D12Mit8.
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| References |
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Original: |
J:19675
Jacoby RF et al.,
"Genetic analysis of colon cancer susceptibility in mice."
Genomics 1994 Jul 15;22(2):381-7
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All: |
1 reference(s)
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