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| Nomenclature |
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Symbol:
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Scd2tm1Myz
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Name:
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stearoyl-Coenzyme A desaturase 2;
targeted mutation 1, Makoto Miyazaki
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MGI ID: |
MGI:3603451 |
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Synonyms: |
Scd2- |
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Gene:
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Scd2
Location:
Chr19:44368578-44381350 bp, + strand
Genetic Position: Chr19,
43.0 cM
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Phenotypic appearance of newborn and adult Scd2tm1Myz/Scd2tm1Myz mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:101158
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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A targeting vector was designed to replace exons 1-6 of the locus, the entire coding sequence. Expression was absent in mutant brains. (J:101158) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
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expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:101158
Miyazaki M et al.,
"Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development."
Proc Natl Acad Sci U S A 2005 Aug 30;102(35):12501-6
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All: |
1 reference(s)
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