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| Nomenclature |
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Symbol:
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Tg(Pcp2-tTA)3Horr
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Name:
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transgene insertion 3, Harry T Orr
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MGI ID: |
MGI:3580157 |
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Transgene:
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Tg(Pcp2-tTA)3Horr
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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This transgene expresses the tetracycline transactivator (tTA) under control of the 5' sequences, including the first exon, the first intron and part of the second exon, of the Purkinje-cell specific mouse Purkinje cell protein 2 gene. (J:95453) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Transgene mRNA levels in cerebella of mice of nine independent transgenic lines were assayed by Northern blot analysis of cerebellar extracts. The highest-expressing line was selected to cross with mice bearing a TetO-driven transgene.
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| References |
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Original: |
J:95453
Zu T et al.,
"Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice."
J Neurosci 2004 Oct 6;24(40):8853-61
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All: |
2 reference(s)
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