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| Nomenclature |
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Symbol:
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Pcsk9tm1Jdh
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Name:
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proprotein convertase subtilisin/kexin type 9;
targeted mutation 1, Jay D Horton
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MGI ID: |
MGI:3577021 |
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Synonyms: |
Pcsk9- |
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Gene:
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Pcsk9
Location:
Chr4:106114934-106136934 bp, - strand
Genetic Position: Chr4,
Syntenic
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:97836
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutation: |
Disruption caused by insertion of vector |
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A targeting vector containing a neomycin resistance gene was inserted to replace the 3' half of exon 2 through exon 4. Northern blot of mutant livers confirmed absence of transcript. Immunoblot of livers further confirmed absence of protein. (J:97836) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:97836
Rashid S et al.,
"Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9."
Proc Natl Acad Sci U S A 2005 Apr 12;102(15):5374-9
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All: |
3 reference(s)
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