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| Nomenclature |
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Symbol:
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Notch1tm3(cre)Rko
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Name:
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Notch gene homolog 1 (Drosophila);
targeted mutation 3, Raphael Kopan
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MGI ID: |
MGI:3514150 |
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Synonyms: |
N1::cre, N1::cretg |
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Gene:
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Notch1
Location:
Chr2:26313423-26372183 bp, - strand
Genetic Position: Chr2,
15.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:119910
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: |
Targeted (knock-in) |
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Mutation: |
Insertion |
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The intracellular domain was replaced with cre recombinase. (J:119910) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Recombinase specificity
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Driver:
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Notch1
Summary of all recombinase alleles
driven by Notch1.
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MGI has not yet included tissue specificity data for this allele in any anatomical systems.
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:119910
Vooijs M et al.,
"Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE."
Development 2007 Feb;134(3):535-44
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All: |
1 reference(s)
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