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| Nomenclature |
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Symbol:
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Tg(Ela1-TAg*)289Mjt
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Name:
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transgene insertion 289, Mary J Tevethia
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MGI ID: |
MGI:3510408 |
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Synonyms: |
T1-147 |
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Transgene:
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Tg(Ela1-TAg*)289Mjt
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(B6D2F1/J x C57BL/6)
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The E1-T147 transgene was designed with a 4.3 kb rat elastase 1 (Ela1 or E1) gene upstream control region, LTR stabilizer, and SV40 late 16S splice site all upstream of the simian virus 40 large T antigen (TAg) coding sequence for amino acids 1-147 (with stop codon introduced at amino acid 148) and polyA sequence. The T1-147 transgenic mice (founder line 289) mice were established. (J:78026) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
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Tg(Ela1-TAg*)289Mjt/0 |
involves: C57BL/6 * DBA/2 |
life span/aging growth/size tumorigenesis digestive/alimentary system endocrine/exocrine glands |
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| References |
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Original: |
J:78026
Tevethia MJ et al.,
"A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice."
J Virol 1997 Nov;71(11):8157-66
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All: |
2 reference(s)
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