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| Nomenclature |
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Symbol:
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Sncatm1Sud
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Name:
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synuclein, alpha;
targeted mutation 1, Thomas C Sudhof
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MGI ID: |
MGI:3487373 |
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Synonyms: |
alpha- |
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Gene:
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Snca
Location:
Chr6:60681573-60778833 bp, - strand
Genetic Position: Chr6,
29.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:93686
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutation: |
Disruption caused by insertion of vector |
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The first coding exon, encoding residues 1-40, was deleted via homologous recombination. Immunoblotting confirmed the lack of protein in mutant mice brains. (J:93686) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:93686
Schluter OM et al.,
"Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice."
Neuroscience 2003;118(4):985-1002
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All: |
3 reference(s)
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