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| Nomenclature |
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Symbol:
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Tg(GFAP-APOE*2)14Hol
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Name:
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transgene insertion 14, David M Holtzman
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MGI ID: |
MGI:3057185 |
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Synonyms: |
GFAP-apoE2 line14, Tg(GFAP-APOE2)14Hol |
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Transgene:
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Tg(GFAP-APOE*2)14Hol
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 and CBA
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The transgene contains sequence encoding human apolipoprotein E2 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. (J:93487) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Notes |
Transgenic mice do not express endogenous mouse apolipoprotein E (APOE). The expression pattern of the transgenic human apolipoprotein E2 isoform (APOE2) follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE2 is immunodetectable in glia and neuropil in developing and adult mutant mice. Cultured astrocytes from transgenic mice secrete APOE2 in lipoproteins that are similar in size to high density plasma lipoproteins (HDL). Detergent-soluble APOE2 protein levels in forebrain tissue from hemizygous mice and in adult human cortex tissue are similar. Mice that are hemizygous or homozygous for the transgenic insert and homozygous for Apoetm1Unc are viable, normal in size, and do not display any gross physical or behavioral abnormalities.
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| References |
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Original: |
J:93487
Sun Y et al.,
"Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins."
J Neurosci 1998 May 1;18(9):3261-72
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All: |
2 reference(s)
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