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| Nomenclature |
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Symbol:
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Tg(Prnp-SNCA*A53T)83Vle
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Name:
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transgene insertion 83, Virginia M-Y Lee
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MGI ID: |
MGI:3057167 |
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Synonyms: |
A53T alpha-synuclein PRP, alphaS+, M83, Tg(SNCA)83Vle |
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Transgene:
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Tg(Prnp-SNCA*A53T)83Vle
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x C3H
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The transgene contains the mouse prion protein promoter, its 5' and 3' untranslated regions, and a human alpha synuclein cDNA sequence encoding a mutated protein with an Ala53Thr mutation. Transgene expression was detected in the cerebral cortex, spinal cord, and cerebellum. (J:76657) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Notes |
This line was originally designated M83. Line M91 was also generated.
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| References |
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Original: |
J:76657
Giasson BI et al.,
"Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein."
Neuron 2002 May 16;34(4):521-33
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All: |
6 reference(s)
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