Tg(PDGFB-APPSwInd)20Lms Transgene Detail MGI Mouse (MGI:3057148)

Tg(PDGFB-APPSwInd)20Lms
Transgene Detail

Nomenclature

Symbol:	Tg(PDGFB-APPSwInd)20Lms
Name:	transgene insertion 20, Lennart Mucke
MGI ID:	MGI:3057148
Synonyms:	APP Tg, J20, PDGF-APPSwInd, PDGF-hAPP695,751,770V171F, KM670/671NL
Transgene:	Tg(PDGFB-APPSwInd)20Lms Location: unknown

Transgene
origin

Strain of Origin:

(C57BL/6 x DBA/2)F2

Transgene
description

Transgene Type:	Transgenic (random, expressed)
Mutation:	Insertion
	The transgene expresses the mutant human amyloid protein precursor APPSwInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the human platelet derived growth factor, B polypeptide (PDGFB) promoter. Hemizygous transgenic mice express immunodetectable transgene product in cerebral neurons, with the highest level of expression occurring in the neocortex and hippocampus. ELISA analysis reveals approximate total amyloid beta peptides and 42 amino acid length amyloid beta peptides in neocortical and hippocampal tissue from transgenic mice. (J:62290)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	tg1	tg2	tg3	tg4	tg5	tg6	tg7	tg8	tg9
behavior/neurological				√	√	√	√	√
behavior/neurological phenotype					N	N	N	N
increased susceptibility to pharmacologically induced seizures				√
decreased anxiety-related response				√	√	√
abnormal long term object recognition memory				√
abnormal spatial learning				√	√	√		√
hyperactivity				√
decreased susceptibility to pharmacologically induced seizures							√	√
		tg1	tg2	tg3	tg4	tg5	tg6	tg7	tg8	tg9
life span/aging				√	N	N			√	√
life span/aging phenotype					N	N
premature death				√					√	√
		tg1	tg2	tg3	tg4	tg5	tg6	tg7	tg8	tg9
nervous system		√	√	√			√	√	√	√
abnormal neuron morphology			√	√			√	√
abnormal pyramidal neuron morphology		√
abnormal neurite morphology									√	√
amyloid beta deposits			√	√			√	√	√	√
increased susceptibility to pharmacologically induced seizures				√
abnormal neurogenesis				√			√	√
neurodegeneration				√
decreased susceptibility to pharmacologically induced seizures							√	√
gliosis									√	√
astrocytosis									√	√
		tg1	tg2	tg3	tg4	tg5	tg6	tg7	tg8	tg9
other phenotype			√	√			√	√	√	√
amyloid beta deposits			√	√			√	√	√	√

		tg1	tg2	tg3	tg4	tg5	tg6	tg7	tg8	tg9
Disease Models				√
Alzheimer Disease; AD				√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype

Allelic Composition

Genetic Background

tg1

Tg(PDGFB-APPSwInd)20Lms/0

B6.Cg-Tg(PDGFB-APPSwInd)20Lms

tg2

Tg(PDGFB-APPSwInd)20Lms/0

B6.D2-Tg(PDGFB-APPSwInd)20Lms

tg3 Disease Model

Tg(PDGFB-APPSwInd)20Lms/0

involves: C57BL/6 * DBA/2

tg4

Pla2g4a^tm1Jvb/Pla2g4a⁺
Tg(PDGFB-APPSwInd)20Lms/0

involves: 129S4/SvJae * C57BL/6 * DBA/2

tg5

Pla2g4a^tm1Jvb/Pla2g4a^tm1Jvb
Tg(PDGFB-APPSwInd)20Lms/0

involves: 129S4/SvJae * C57BL/6 * DBA/2

tg6

Mapt^tm1Hnd/Mapt^tm1Hnd
Tg(PDGFB-APPSwInd)20Lms/0

involves: C57BL/6 * DBA/2

tg7

Mapt^tm1Hnd/Mapt⁺
Tg(PDGFB-APPSwInd)20Lms/0

involves: C57BL/6 * DBA/2

tg8

Tg(Camk2a-IDE)1Selk/0
Tg(PDGFB-APPSwInd)20Lms/0

involves: C57BL/6 * DBA/2

tg9

Tg(Camk2a-MME)3Selk/0
Tg(PDGFB-APPSwInd)20Lms/0

involves: C57BL/6 * DBA/2

Disease
models

Mouse Models of Human Disease	Note	Genotype			Ref(s)
			Allelic Composition	Genetic Background
Models involving transgenes or other mutation types.¹
Alzheimer Disease; AD OMIM ID: 104300		tg3	Tg(PDGFB-APPSwInd)20Lms/0	involves: C57BL/6 * DBA/2	J:62290

¹Models involving transgenes or other mutation types may also appear in other sections of the table.

Notes

This line is also called line J20.

Diffuse amyloid beta peptides deposition forms in the dendate gyrus and neocortex at 5 to 7 months of age. Amyloid deposition is progressive, with all transgenic mice exhibiting plaques by age 8 to 10 months.

References

Original:	J:62290 Mucke L et al., "High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation." J Neurosci 2000 Jun 1;20(11):4050-8
All:	43 reference(s)

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