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Tg(tTALap)5Bjd
Transgene Detail

Nomenclature
Symbol: Tg(tTALap)5Bjd
Name: transgene insertion 5, Hermann Bujard
MGI ID: MGI:3056818
Synonyms: LAP-tTA, Tg(tTALap)5Uh
Transgene: Tg(tTALap)5Bjd   Location: unknown    
Transgene
origin
Strain of Origin: NMRI
Transgene
description
Transgene Type: Transgenic (random, expressed)
Mutation: Insertion
  This transgene contains the gene encoding the tetracycline regulated transactivator protein (tTA) driven by the rat Cebpb promoter (previously called liver-enriched activator protein). (J:93000)
Find Mice (IMSR) Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
tg1
 
tg2
 
tg3
 
tg4
 
tg5
 
tg6
  
cardiovascular system          		   √  
  
growth/size          		    √ 
  
homeostasis/metabolism          		√√ N  
  
lethality/postnatal          		√√    
  
lethality/prenatal-perinatal          		   √  
  
life span/aging          		√√  √√
  
liver/biliary system          		  √√√ 
  
tumorigenesis          		    √√
 
  
Disease Models          		√√  √√
Phenotypic
data by
genotype
Phenotypic Data by Genotype

(show or hide all phenotypic details)

GenotypeAllelic CompositionGenetic Background
  
 tg1   Disease Model  		 Dbttm1Geh/Dbttm1Geh
Tg(tetO-DBT)A1Geh/0
Tg(tTALap)5Bjd/0		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI
  
 tg2   Disease Model  		 Dbttm1Geh/Dbttm1Geh
Tg(tetO-DBT)525AGeh/0
Tg(tTALap)5Bjd/0		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI
  
 tg3   		 Kdrtm1Jrt/Kdr+
Tg(tetO-Kdr*)4377.5Rwng/0
Tg(tTALap)5Bjd/0		 involves: 129S1/Sv * 129X1/SvJ * FVB/N * NMRI
  
 tg4   		 Tg(tetO-Kdr*)4377.5Rwng/0
Tg(tTALap)5Bjd/0		 involves: FVB/N * NMRI
  
 tg5   Disease Model  		 Tg(tetO-MET)23Rwng/0
Tg(tTALap)5Bjd/0		 involves: FVB/N * NMRI
  
 tg6   Disease Model  		 Tg(tetO-MYC)36Bop/0
Tg(tTALap)5Bjd/0		 involves: FVB/N * NMRI
Disease
models
Mouse Models
of Human Disease
NoteGenotypeRef(s)
 
Allelic Composition
Genetic Background
Models involving transgenes or other mutation types.1
Hepatocellular Carcinoma
OMIM ID: 114550		  
 
tg5		Tg(tetO-MET)23Rwng/0
Tg(tTALap)5Bjd/0		involves: FVB/N * NMRIJ:69731
 
 
tg6		Tg(tetO-MYC)36Bop/0
Tg(tTALap)5Bjd/0		involves: FVB/N * NMRIJ:93899
Maple Syrup Urine Disease
OMIM ID: 248600		  
 
tg1		Dbttm1Geh/Dbttm1Geh
Tg(tetO-DBT)A1Geh/0
Tg(tTALap)5Bjd/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRIJ:119973
 
 
tg2		Dbttm1Geh/Dbttm1Geh
Tg(tetO-DBT)525AGeh/0
Tg(tTALap)5Bjd/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRIJ:119973
1Models involving transgenes or other mutation types may also appear in other sections of the table.
Notes Transgenic mice on a C57BL/6J background are viable and fertile, and express tTA in the liver.
References
Original: J:93000 Kistner A et al., "Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice." Proc Natl Acad Sci U S A 1996 Oct 1;93(20):10933-8
All: 17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
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