|
|
| Nomenclature |
|
Symbol:
|
Trp53tm4Tyj
|
|
Name:
|
transformation related protein 53;
targeted mutation 4, Tyler Jacks
|
|
MGI ID: |
MGI:3056071 |
|
Synonyms: |
S23A |
|
Gene:
|
Trp53
Location:
Chr11:69393861-69405375 bp, + strand
Genetic Position: Chr11,
39.0 cM, cytoband B2-C
|
|
Mutation
origin |
|
Germline Transmission:
| Earliest citation of germline transmission:
J:92917
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: |
Targeted (knock-in) |
|
Mutation: |
Nucleotide substitutions |
| |
A serine to alanine mutation was created at position 23 in exon 2. Transient cre recombinase expression excised a floxed puromycin resistance cassette that was introduced with the mutation. RT-PCR of mutant MEFs confirmed correct targeting. (J:92917) |
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Phenotype
summary
|
|
Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
|
Key:
|
| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
|
|
|
|
|
Phenotypic
data by
genotype
|
|
Phenotypic Data by Genotype
(show or
hide all phenotypic details)
|
| Genotype | Allelic Composition | Genetic Background |
|
  hm1
|
Trp53tm4Tyj/Trp53tm4Tyj |
involves: 129S4/SvJae * C57BL/6 |
life span/aging tumorigenesis cellular |
|
|
| References |
|
Original: |
J:92917
MacPherson D et al.,
"Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23."
EMBO J 2004 Sep 15;23(18):3689-99
|
|
All: |
2 reference(s)
|
|
