|
|
| Nomenclature |
|
Symbol:
|
Tg(Eno2tTA)5021Nes
|
|
Name:
|
transgene insertion 5021, Eric Nestler
|
|
MGI ID: |
MGI:3053186 |
|
Synonyms: |
line B, NSE-tTA |
|
Transgene:
|
Tg(Eno2tTA)5021Nes
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
(SJL x C57BL/6)F1
|
|
Transgene
description |
|
Transgene
Type: |
Transgenic (random, expressed) |
|
Mutation: |
Insertion |
| |
This transgene consists of a 1.8kb fragment of the rat Eno2 promoter, an SV40 intron, a poly A signal sequence, and a modified tetracycline transactivator cDNA. (J:92225) |
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
B6.Cg-TgN(Eno2tTA)5021Nes mice selectively express tTA at high levels in the striatum and cerebellum. When these transgenic mice are mated to a second transgenic strain which carries a gene of interest under the regulation of a tetracycline-responsive promoter element (TRE), expression of the target gene in the bitransgenic offspring may be induced in those tissues where tTA is expressed by the withdrawal of the tetracycline analog, doxycycline (dox).
|
| References |
|
Original: |
J:92225
Chen J et al.,
"Transgenic animals with inducible, targeted gene expression in brain."
Mol Pharmacol 1998 Sep;54(3):495-503
|
|
All: |
7 reference(s)
|
|
