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| Nomenclature |
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Symbol:
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Tg(tetFosb)4468Nes
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Name:
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transgene insertion 4468, Eric Nestler
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MGI ID: |
MGI:3053111 |
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Synonyms: |
TetOp-*FosB line 11, TetOp-deltaFosB line 11 |
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Transgene:
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Tg(tetFosb)4468Nes
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(SJL x C57BL/6)F1
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The transgene contains a Fosb cDNA under the control of a tetracycline-regulated promoter, an SV40 intron, and a poly A signal sequence. (J:92225) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Homozygous transgenic mice are viable and fertile. These mice express a truncated variant of the Fosb transcription factor. The expressed variant is a highly stable isoform found to be induced in the brain (nucleus accumbens) with repeated exposure to commonly abused drugs, such as amphetamine, morphine, nicotine, and phencyclidine. Transcription is directed by a tetracycline-responsive promoter element (TRE). In bitransgenic mice produced by breeding a mouse carrying this transgene with a transgenic mouse expressing tetracycline-controlled transactivator protein (tTA), Fosb expression can be negatively regulated with the tetracycline analog, doxycycline.
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| References |
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Original: |
J:92225
Chen J et al.,
"Transgenic animals with inducible, targeted gene expression in brain."
Mol Pharmacol 1998 Sep;54(3):495-503
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All: |
11 reference(s)
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