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| Nomenclature |
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Symbol:
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Tg(Ins2-TAg)1Lt
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Name:
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transgene insertion 1, Edward H Leiter
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MGI ID: |
MGI:3052662 |
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Synonyms: |
Tg(RipTAg)1Lt |
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Transgene:
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Tg(Ins2-TAg)1Lt
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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NOD/ShiLt
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The transgene contains rat insulin 2 promoter (Rip) and the wild-type allele of the SV40 large T antigen (TAg) gene. (J:92449) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
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Tg(Ins2-TAg)1Lt/0 |
NOD/ShiLt-Tg(Ins2-TAg)1Lt |
tumorigenesis |
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Notes |
Homozygous transgenic mice on an NOD/Lt genetic background develop pancreatic beta cell adenomas. They are able to produce 2-3 litters before the insulin secreted from the adenoma makes them too hypoglycemic.
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| References |
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Original: |
J:92449
Hamaguchi K et al.,
"NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse."
Diabetes 1991 Jul;40(7):842-9
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All: |
2 reference(s)
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