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| Nomenclature |
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Symbol:
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Tg(Eno2tTA)5030Nes
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Name:
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transgene insertion 5030, Eric Nestler
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MGI ID: |
MGI:3051985 |
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Synonyms: |
A line, NSE-tTA, Tg(Eno2-tTA)ANes |
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Transgene:
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Tg(Eno2tTA)5030Nes
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(SJL x C57BL/6)F1
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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This transgene consists of a 1.8kb fragment of the rat Eno2 promoter, an SV40 intron, a poly A signal sequence, and a modified tetracycline transactivator cDNA. (J:92225) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Notes |
B6.Cg-TgN(Eno2tTA)5030Nes mice selectively express tTA at high levels in the striatum and to a lesser extent in the cerebral cortex and hippocampus. When these transgenic mice are mated to a second transgenic strain which carries a gene of interest under the regulation of a tetracycline-responsive promoter element (TRE), expression of the target gene in the bitransgenic offspring may be induced in those tissues where tTA is expressed by the withdrawal of the tetracycline analog, doxycycline (dox).
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| References |
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Original: |
J:92225
Chen J et al.,
"Transgenic animals with inducible, targeted gene expression in brain."
Mol Pharmacol 1998 Sep;54(3):495-503
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All: |
23 reference(s)
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