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| Nomenclature |
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Symbol:
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Hc1
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Name:
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hemolytic complement;
sufficient
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MGI ID: |
MGI:3044820 |
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Synonyms: |
C5 sufficient, C5-s, C5-suf |
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Gene:
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Hc
Location:
Chr2:34838851-34916958 bp, - strand
Genetic Position: Chr2,
23.5 cM, cytoband cen-C1
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Mutation
description |
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Allele
Type: |
Not Applicable |
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Mutation: |
Not Applicable |
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This allele does not contain the 2 base "TA" deletion found in the Hc0 allele and is found in the following mouse strains BALB/cJ, C57BL/6J, DBA/1J, and B10.D2/nSnJ. This is equivalent to the wild-type allele.
(J:23983) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Notes |
Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The C3H/HeJ allele does not have the 2 bp deletion and is associated with resistance to allergen-induced bronchial hyperresponsiveness. (J:108211)
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| References |
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Original: |
J:5016
Nilsson UR et al.,
"Deficiency of the fifth component of complement in mice with an inherited complement defect."
J Exp Med 1967 Jan 1;125(1):1-16
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All: |
22 reference(s)
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