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| Nomenclature |
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Symbol:
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Notch1tm2Rko
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Name:
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Notch gene homolog 1 (Drosophila);
targeted mutation 2, Raphael Kopan
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MGI ID: |
MGI:3044585 |
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Synonyms: |
fN1, Notch1flox, Notch1tm1Shn |
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Gene:
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Notch1
Location:
Chr2:26313423-26372183 bp, - strand
Genetic Position: Chr2,
15.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:90392
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: |
Targeted (Floxed/Frt) |
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Mutation: |
Insertion |
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LoxP were inserted flanking the first coding exon of the gene. An adjacent loxP flanked neomycin cassette was removed by Cre-mediated recombination in ES cells prior to production of chimeric animals. (J:90392) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:90392
Yang X et al.,
"Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway."
Dev Biol 2004 May 1;269(1):81-94
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All: |
11 reference(s)
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