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| Nomenclature |
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Symbol:
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Tg(Ins1-Cat,Tyr)25Pne
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Name:
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transgene insertion 25, Paul N Epstein
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MGI ID: |
MGI:3043843 |
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Synonyms: |
RipCat |
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Transgene:
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Tg(Ins1-Cat,Tyr)25Pne
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The symbol represents a double transgene. In one transgene, a rat insulin I promoter drives the expression of a rat catalase cDNA. Northern blot analysis and immunohistochemistry detected expression of this transgene in pancreatic beta cells. A second transgene that expresses tyrosinase under control of the tyrosinase promoter was coinjected with the first transgene, and apparently cosegregated.
(J:59725) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
|
  tg1
Disease Model |
Tg(Ins1-Cat,Tyr)25Pne/0 |
involves: FVB |
homeostasis/metabolism endocrine/exocrine glands digestive/alimentary system 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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| Genotype | Allelic Composition | Genetic Background |
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tg2
Disease Model |
Tg(Ins1-Cat,Tyr)25Pne/0 |
NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne |
homeostasis/metabolism immune system endocrine/exocrine glands digestive/alimentary system 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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| References |
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Original: |
J:59725
Xu B et al.,
"Overexpression of catalase provides partial protection to transgenic mouse beta cells."
Free Radic Biol Med 1999 Oct;27(7-8):830-7
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All: |
3 reference(s)
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