|
|
| Nomenclature |
|
Symbol:
|
Tg(MMTVTGFA)254Rjc
|
|
Name:
|
transgene insertion 254, Robert J Coffey
|
|
MGI ID: |
MGI:3040319 |
|
Transgene:
|
Tg(MMTVTGFA)254Rjc
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
(C57BL/6 x DBA/2)F2
|
|
Transgene
description |
|
Transgene
Type: |
Transgenic (random, expressed) |
|
Mutation: |
Insertion |
| |
The transgene contains the mouse mammary tumor virus LTR and the normal allele of the human transforming growth factor alpha gene. The vector also contains exons 2 and 3 of the rabbit beta-globin gene. Lines 254, 257, 64 and 29 were produced. (J:28453) |
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Phenotype
summary
|
|
Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
|
Key:
|
| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
|
|
|
|
|
Phenotypic
data by
genotype
|
|
Phenotypic Data by Genotype
(show or
hide all phenotypic details)
|
| Genotype | Allelic Composition | Genetic Background |
|
  tg1
|
Tg(MMTVTGFA)254Rjc/0 |
involves: C57BL/6 * DBA/2 |
endocrine/exocrine glands tumorigenesis behavior/neurological skin/coat/nails reproductive system |
|
|
| References |
|
Original: |
J:28453
Matsui Y et al.,
"Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice."
Cell 1990 Jun 15;61(6):1147-55
|
|
All: |
8 reference(s)
|
|
