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| Nomenclature |
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Symbol:
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Trp53tm2.1Tyj
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Name:
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transformation related protein 53;
targeted mutation 2.1, Tyler Jacks
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MGI ID: |
MGI:3039264 |
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Synonyms: |
p53 R172H, p53R172H, TrpR172H |
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Gene:
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Trp53
Location:
Chr11:69393861-69405375 bp, + strand
Genetic Position: Chr11,
39.0 cM, cytoband B2-C
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:95316
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: |
Targeted (knock-in) |
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Mutation: |
Nucleotide substitutions |
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The loxP flanked stop cassette was removed from Trp53tm2Tyj via cre-mediated recombination, leaving an R172H missense mutation in exon 5. Quantitative real-time PCR confirmed that the point mutation allele is expressed at a level comparable to wild-type. (J:95316) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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| References |
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Original: |
J:95316
Olive KP et al.,
"Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome."
Cell 2004 Dec 17;119(6):847-60
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All: |
4 reference(s)
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