Tg(C3-1-TAg)cJeg Transgene Detail MGI Mouse (MGI:3039067)

Tg(C3-1-TAg)cJeg
Transgene Detail

Nomenclature

Symbol:	Tg(C3-1-TAg)cJeg
Name:	transgene insertion c, Jeffrey E Green; transgene insertion C, Jeffrey E Green
MGI ID:	MGI:3039067
Synonyms:	C3(1)-SV40 T antigen, C3(1)/SV40, C3(1)/SV40T, C3(1)/T antigen (Tag), C3(1)/T(AG), C3(1)/TAg, Large T
Transgene:	Tg(C3-1-TAg)cJeg Location: unknown

Transgene
origin

Strain of Origin:

FVB/N

Transgene
description

Transgene Type:	Transgenic (random, expressed)
Mutation:	Insertion
	This transgene contains the rat prostatic binding protein C3 promoter (Pbpc3) and the wild-type allele of the SV40 large tumor antigen (TAg) gene. Founder c carried 6 copies of the transgene. Founders f, g, i, j, k, and l were also generated. Two transgenic lines (c and l) were produced. (J:52786)

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:

Mouse Strains: 3 strains available Cell Lines: 0 lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	tg1
endocrine/exocrine glands		√
mammary gland hyperplasia		√
abnormal prostate physiology		√
		tg1
reproductive system		√
mammary gland hyperplasia		√
abnormal prostate physiology		√
		tg1
tumorigenesis		√
increased tumor incidence		√
adenocarcinoma		√
mammary adenocarcinoma		√
prostate adenocarcinoma		√
prostate intraepithelial neoplasia		√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype

Allelic Composition

Genetic Background

tg1

Tg(C3-1-TAg)cJeg/0

involves: FVB/N

tumorigenesisincreased tumor incidence (J:46513)

some mice exhibit mixed tumors of the sweat glands and occasional nasal proliferative or neoplastic lesions develop from the nasal turbinate epithelium unlike in wild-type mice

adenocarcinoma (J:46513)

at 7 months, 10% to 20% male mice develop adenocarcinomas of the urethral and bulbourethral glands unlike in wild-type mice

mammary adenocarcinoma (J:52786, J:46513)

by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice (J:46513)

at 6 months, 10% of female mice exhibit lung metastasis (J:46513)

adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice (J:46513)

prostate adenocarcinoma (J:72324, J:46513)

at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice (J:72324)

after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice (J:72324)

the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)

at 7 months in the ventral prostate and 11 months in the dorsolateral prostate (J:46513)

however, no metastasis is observed (J:46513)

prostate intraepithelial neoplasia (J:72324, J:46513)

at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice (J:72324)

low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice (J:72324)

at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice (J:72324)

high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice (J:72324)

numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice (J:72324)

the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)

at 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice (J:46513)

at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice (J:46513)

PIN lesions increase with age (J:46513)

endocrine/exocrine glandsmammary gland hyperplasia (J:46513)

at 2 months of age, female mice exhibit atypical ductal hyperplasias unlike in wild-type mice

hyperplastic cells exhibit increased rates of apoptosis compared to cells in wild-type mice

abnormal prostate physiology (J:46513)

prostate cells exhibit increased proliferation and apoptosis rates compared to in wild-type mice according to their degree of prostate intraepithelial neoplasia

reproductive systemmammary gland hyperplasia (J:46513)

at 2 months of age, female mice exhibit atypical ductal hyperplasias unlike in wild-type mice

hyperplastic cells exhibit increased rates of apoptosis compared to cells in wild-type mice

abnormal prostate physiology (J:46513)

prostate cells exhibit increased proliferation and apoptosis rates compared to in wild-type mice according to their degree of prostate intraepithelial neoplasia

References

Original:	J:52786 Maroulakou IG et al., "Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene." Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11236-40
All:	40 reference(s)

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