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| Nomenclature |
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Symbol:
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Psen1tm1Vln
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Name:
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presenilin 1;
targeted mutation 1, Fred Van Leuven
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MGI ID: |
MGI:2684616 |
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Synonyms: |
PS1-flox |
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Gene:
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Psen1
Location:
Chr12:85029513-85076149 bp, + strand
Genetic Position: Chr12,
37.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:87229
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: |
Targeted (Floxed/Frt) |
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Mutation: |
Insertion |
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Exon 7 was flanked by a single loxP site in intron 6 and floxed neo cassette in intron 7. (J:87229) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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1Conditionally targeted allele(s).
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| References |
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Original: |
J:87229
Dewachter I et al.,
"Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice."
J Neurosci 2002 May 1;22(9):3445-53
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All: |
5 reference(s)
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