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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1(Notch1)Dam
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Douglas A Melton
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MGI ID: |
MGI:2684314 |
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Synonyms: |
Lox-stop-Lox-RosaNICD-ires-GFP, R-NICD, Rosa-NotchIC-IRES-GFP, RosaN1-IC, RosaNICD, RosaNotch, Rosa26NIC |
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Gene:
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Gt(ROSA)26Sor
Location:
unknown
Genetic Position: Chr6,
48.7 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:86975
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: |
Targeted (knock-in) |
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Mutation: |
Insertion |
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A targeting vector containing a floxed neo cassette followed by a mouse Notch1 sequence fragment and GFP was inserted at the endogenous locus. Excision of the floxed neo cassette leads to the expression of the Notch1 sequence encoding an intracellular portion of NOTCH1 (amino acids 1749-2293), but lacking the c-terminal PEST domain. IRES preceded the sequence encoding the nuclear-localized enhanced GFP. (J:86975) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:86975
Murtaugh LC et al.,
"Notch signaling controls multiple steps of pancreatic differentiation."
Proc Natl Acad Sci U S A 2003 Dec 9;100(25):14920-5
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All: |
21 reference(s)
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