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| Nomenclature |
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Symbol:
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Sncgtm1Vlb
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Name:
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synuclein, gamma;
targeted mutation 1, Vladimir L Buchman
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MGI ID: |
MGI:2683142 |
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Synonyms: |
TgHSNCGtm1VLB |
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Gene:
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Sncg
Location:
Chr14:35183460-35187975 bp, - strand
Genetic Position: Chr14,
12.5 cM, cytoband B-C
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:86439
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutation: |
Disruption caused by insertion of vector |
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Exons 1 through 3 were replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from various tissues. Western blot analysis of total spinal cord protein indicated an absence of protein in homozygous mutant mice. (J:86439) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:86439
Ninkina N et al.,
"Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene."
Mol Cell Biol 2003 Nov;23(22):8233-45
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All: |
4 reference(s)
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