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| Nomenclature |
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Symbol:
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chtl
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Name:
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chocolate-like
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MGI ID: |
MGI:2675597 |
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Gene:
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chtl
Location:
unknown
Genetic Position: Chr7,
44.0 cM
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Mutation
origin |
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Strain of Origin:
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B6.129P2-Nos2tm1Lau/J
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Undefined |
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The chocolate-like spontaneous mutation was found at The Jackson Laboratory in 1998. A test for allelism to the cht locus demonstrated that the two mutations are in pseudoalleles or that modifier genes in the two background strains can affect the phenotype expression. |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
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chtl/chtl |
B6.129P2-Nos2tm1Lau/J |
pigmentation skin/coat/nails |
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Notes |
A test for allelism with homozygous cht mouse mated to a homozygous mutant mouse produced 32/32 progeny with a dull grey phenotype, unlike cht or a/a . These results suggested chtl is a new allele of the cht gene that produces a different phenotype from the original cht allele. When two matings of the grey color F1s from the allele test progeny were mated together, however, they produced segregating litters for a total of 10 cht looking mice and 3 normal black a/a mice. The appearance of the black mice means either the two mutations are pseudoalleles or modiefier genes can affect the phenotype expresssion.
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| References |
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Original: |
J:82799
Ward-Bailey PF et al.,
"Chocolate-like, a spontaneous mutation causing a dark brown coat color in the mouse. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr)"
MGI Direct Data Submission 2003;():
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All: |
1 reference(s)
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