Symbol
Name
ID
|
Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
MGI:2673307
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Nomenclature History
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Synonyms
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RIPE3b1
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Genetic Map
|
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Chromosome 15
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Syntenic
|
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Mapping data(
2)
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Sequence Map
|
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Mammalian
homology
|
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Sequences
|
All sequences(13)
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Alleles
and
phenotypes
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All alleles(2) :
Targeted, knock-out(1)
Targeted, other(1)
| Homozygous mutant mice exhibit glucose intolerance and develop diabetes mellitus. Glucose-stimulated insulin secretion is severely impaired and mutant mice display pancreatic islet abnormalities as they age. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (1)
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Gene Ontology
(GO)
classifications
|
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Expression
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Literature Summary: (20 records)
Data Summary:
Assays (2)
Results (8)
Tissues (6)
Images (3)
Theiler Stages: 19,21,23,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
1 |
|
6 |
| |
Immunohistochemistry |
1 |
|
2 |
cDNA source data(7)
External Resources:
GEO
|
Molecular
reagents
|
All nucleic(10)
cDNA(7)
Primer pair(2)
Other(1)
Antibodies(1)
Microarray probesets(1)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR004826 |
Maf transcription factor |
| IPR004827 |
Basic-leucine zipper (bZIP) transcription factor |
| IPR008917 |
Eukaryotic transcription factor, Skn-1-like, DNA-binding |
| IPR013592 |
Maf transcription factor, N-terminal |
Graphical View
of Protein Domain Structure
|
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References
|
(Earliest)
J:80902
Kataoka K et al.,
"MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene."
J Biol Chem 2002 Dec 20;277(51):49903-10
(Latest)
J:154416
Du A et al.,
"Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas."
Diabetes 2009 Sep;58(9):2059-69
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All references(28)
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Analysis Tools
MGI BioMart