Symbol
Name
ID
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Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
MGI:2673307
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Nomenclature History
|
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Synonyms
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RIPE3b1
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Genetic Map
|
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Chromosome 15
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Syntenic
|
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Mapping data(
2)
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(13)
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Alleles
and
phenotypes
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All alleles(1) :
Targeted, other(1)
| Homozygous mutant mice exhibit glucose intolerance and develop diabetes mellitus. Glucose-stimulated insulin secretion is severely impaired and mutant mice display pancreatic islet abnormalities as they age. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (1)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (19 records)
Data Summary:
Assays (2)
Results (8)
Tissues (6)
Images (3)
Theiler Stages: 19,21,23,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
1 |
|
6 |
| |
Immunohistochemistry |
1 |
|
2 |
cDNA source data(7)
External Resources:
GEO
|
Molecular
reagents
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All nucleic(8)
cDNA(7)
Primer pair(1)
Antibodies(1)
Microarray probesets(1)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR004826 |
Maf transcription factor |
| IPR004827 |
Basic-leucine zipper (bZIP) transcription factor |
| IPR013592 |
Maf transcription factor, N-terminal |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:80902
Kataoka K et al.,
"MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene."
J Biol Chem 2002 Dec 20;277(51):49903-10
(Latest)
J:153523
Shimohata H et al.,
"MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic mice develop human-like severe diabetic nephropathy."
Biochem Biophys Res Commun 2009 Nov 13;389(2):235-40
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All references(24)
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