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| Nomenclature |
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Symbol:
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Tg(HD82Gln)81Dbo
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Name:
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transgene insertion 81, David R Borchelt
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MGI ID: |
MGI:2670626 |
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Synonyms: |
N171-82Q, TGN(HD82Gln)81Dbo |
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Transgene:
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Tg(HD82Gln)81Dbo
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under control of a mouse prion protein promoter, which drives transgene expression in the neurons of the central nervous system (J:53797) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
Disease Model |
Tg(HD82Gln)81Dbo/0 |
involves: C3H/HeJ * C57BL/6 |
life span/aging behavior/neurological nervous system 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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| References |
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Original: |
J:53797
Schilling G et al.,
"Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin [published erratum appears in Hum Mol Genet 1999 May;8(5):943]"
Hum Mol Genet 1999 Mar;8(3):397-407
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All: |
24 reference(s)
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