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| Nomenclature |
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Symbol:
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Ahrb-3
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Name:
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aryl-hydrocarbon receptor;
b-3 variant
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MGI ID: |
MGI:2667538 |
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Synonyms: |
Ahb-3 |
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Gene:
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Ahr
Location:
Chr12:36182651-36219661 bp, - strand
Genetic Position: Chr12,
18.0 cM
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Mutation
origin |
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Strain of Origin:
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M. spretus
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Mutation
description |
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Allele
Type: |
Not Applicable |
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Mutation: |
Undefined |
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This allele encodes a high affinity, 105 kDa receptor with slightly more heat stability than the receptor encoded by the BALB/cBy allele. (J:22144) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
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Ahrb-3/Ahrb-3 |
M. spretus |
phenotype not analyzed |
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Notes |
C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460).
Strain of origin - this allele was found in M. caroli, M. spretus, MOLF/Ei strains
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| References |
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Original: |
J:34840
Poland A et al.,
"Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles."
Mol Pharmacol 1990 Sep;38(3):306-12
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All: |
5 reference(s)
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