Ahr<b-1> Allele Detail MGI Mouse (MGI:2667308)

Ahr^b-1
Allele Detail

Nomenclature

Symbol:	Ahr^b-1
Name:	aryl-hydrocarbon receptor; b-1 variant
MGI ID:	MGI:2667308
Synonyms:	Ah, Ah^b-1, Ah^b, Ahhⁱ, Ahr^b, In
Gene:	Ahr Location: Chr12:36182651-36219661 bp, - strand Genetic Position: Chr12, 18.0 cM

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:	Not Applicable
Mutation:	Nucleotide substitutions
	This allele encodes a high affinity, relatively heat stabile, 95 kDa receptor. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). A second C to T transition changes a proline codon in the DBA/2J allele to leucine codon in the C57BL/6J allele, and would likely change secondary structure of the peptide and thus ligand affinity. (J:477, J:15153, J:17460)
Inheritance:	Dominant

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 7 strains available Cell Lines: 0 lines available
Carrying any Ahr Mutation:	39 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	hm2	hm3	hm4	ht5	ht6
homeostasis/metabolism		√	√	√	N	√	√
homeostasis/metabolism phenotype			N		N
increased sensitivity to xenobiotic induced morbidity/mortality		√	√	√		√	√
increased physiological sensitivity to xenobiotics		√	√	√		√
increased incidence of chemically-induced tumors						√
		hm1	hm2	hm3	hm4	ht5	ht6
immune system			√		√
abnormal immune system physiology					√
increased inflammatory response			√
		hm1	hm2	hm3	hm4	ht5	ht6
life span/aging		√	√	√		√	√
increased sensitivity to xenobiotic induced morbidity/mortality		√	√	√		√	√
		hm1	hm2	hm3	hm4	ht5	ht6
tumorigenesis						√
increased incidence of chemically-induced tumors						√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
hm1	Ahr^b-1/Ahr^b-1	C57BL/6
life span/aging increased sensitivity to xenobiotic induced morbidity/mortality (J:113285) mice exhibit neonatal lethality in response to in utero exposure to cHBB unlike mice homozygous for the Ahr^d allele homeostasis/metabolism increased sensitivity to xenobiotic induced morbidity/mortality (J:113285) mice exhibit neonatal lethality in response to in utero exposure to cHBB unlike mice homozygous for the Ahr^d allele increased physiological sensitivity to xenobiotics (J:113285) when mice are fostered by control C57BL/6 dams following in utero exposure to cHBB, 21% of neonates survive mice exhibit neonatal lethality in response to in utero exposure to cHBB and decreased thymus and spleen weights compared to untreated mice following exposure to cHBB in utero, neonates exhibit an increase in volume density of hematopoietic islands in the liver
Genotype	Allelic Composition	Genetic Background
hm2	Ahr^b-1/Ahr^b-1	C57BL/6J
life span/aging increased sensitivity to xenobiotic induced morbidity/mortality (J:26440) mice are susceptible to DMBA induced lethality homeostasis/metabolism homeostasis/metabolism phenotype (J:5387) topical application of the polycyclic hydrocarbon DMBA induced hepatic aryl hydrocarbon hydroxylase activity increased sensitivity to xenobiotic induced morbidity/mortality (J:26440) mice are susceptible to DMBA induced lethality increased physiological sensitivity to xenobiotics (J:132380, J:26440) mice are susepctible to the teratogenic effects of TCDD with 100% of mice developing cleft palates and 90% of mice developing severe hydronephrosis (J:132380) mice are susceptible to the pathological effects of DMBA and exhibit lethality, weight loss, peritonitis, decreased spleen weight, and decreased thymus weight (J:26440) mice exposed to DMBA exhibit decreased lymphocyte counts, increased polymorphic cells, decreased bone marrow cell counts and ascites formation (J:26440) immune system increased inflammatory response (J:5244, J:5387) topical application of the polycyclic hydrocarbon DMBA produced skin inflammation and ulceration (J:5244) topical application of DMBA produced skin inflammation and ulceration (J:5387)
Genotype	Allelic Composition	Genetic Background
hm3	Ahr^b-1/Ahr^b-1	C58/J
life span/aging increased sensitivity to xenobiotic induced morbidity/mortality (J:26440) mice are susceptible to DMBA induced lethality homeostasis/metabolism increased sensitivity to xenobiotic induced morbidity/mortality (J:26440) mice are susceptible to DMBA induced lethality increased physiological sensitivity to xenobiotics (J:26440) mice are susceptible to the pathological effects of DMBA and exhibit lethality, weight loss, peritonitis, decreased spleen weight, and decreased thymus weight
Genotype	Allelic Composition	Genetic Background
hm4	Ahr^b-1/Ahr^b-1	involves: C57BL/6J * DBA/2J
homeostasis/metabolism homeostasis/metabolism phenotype (J:5387) Background Sensitivity: i.p. injection of the polycyclic hydrocarbon 3-methylcholanthrene induced hepatic aryl hydrocarbon hydroxylase activity unlike in strains homozygous for the unresponsive allele immune system abnormal immune system physiology (J:5387) i.p. injection of the polycyclic hydrocarbon 3MC produced skin inflammation and skin ulcers
Genotype	Allelic Composition	Genetic Background
ht5	Ahr^b-1/Ahr^d	involves: 129S1/SvImJ * C57BL/6J
life span/aging increased sensitivity to xenobiotic induced morbidity/mortality (J:113356) mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized homeostasis/metabolism increased sensitivity to xenobiotic induced morbidity/mortality (J:113356) mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized increased physiological sensitivity to xenobiotics (J:113356) mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized however, maternal dietary exposure to I3C increased survival and decreases incidence of lung cancer of offspring exposed to DBP in utero irregardless of offspring or dam genotype increased incidence of chemically-induced tumors (J:113356) offspring exposed to DBP in utero exhibit increased rates of lung cancer and liver tumors in male mice tumorigenesis increased incidence of chemically-induced tumors (J:113356) offspring exposed to DBP in utero exhibit increased rates of lung cancer and liver tumors in male mice
Genotype	Allelic Composition	Genetic Background
ht6	Ahr^b-1/Ahr^d	involves: C57BL/6 * DBA/2
life span/aging increased sensitivity to xenobiotic induced morbidity/mortality (J:113285) like C57BL/6-Ahr^b-1 neonates, mice exhibit neonatal lethality in response to in utero exposure to cHBB homeostasis/metabolism increased sensitivity to xenobiotic induced morbidity/mortality (J:113285) like C57BL/6-Ahr^b-1 neonates, mice exhibit neonatal lethality in response to in utero exposure to cHBB

Notes

C57BL/6 carries the responsive Ahr^b allele; DBA/2 carries nonresponsive Ahr^d. Heterozygotes (Ahr^b/Ahr^d) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahr^b-1; Ahr^b-2 is carried by BALB/cBy, A, and C3H; and Ahr^b-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahr^b-1 and Ahr^d have been determined (J:17460).

Strain of origin - this allele was found in C57BL/6, C58/J, C57BR, MA/My strains

References

Original:	J:26440 Schmid FA et al., "Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice." Cancer Res 1967 Mar;27(3):558-62
All:	38 reference(s)

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