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| Nomenclature |
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Symbol:
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Cd33tm1Ajv
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Name:
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CD33 antigen;
targeted mutation 1, Ajit Varki
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MGI ID: |
MGI:2664507 |
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Synonyms: |
Cd33- |
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Gene:
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Cd33
Location:
Chr7:50783365-50788471 bp, - strand
Genetic Position: Chr7,
23.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:83728
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutation: |
Disruption caused by insertion of vector |
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Exons 1 through 5 were replaced by a pPGK-neo-bpA cassette. Homologous recombination was confirmed by PCR and Southern blot. Loss of gene expression was confirmed by flow cytometric analysis of hematopoietic cells. (J:83728) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
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Cd33tm1Ajv/Cd33tm1Ajv |
involves: 129X1/SvJ * C57BL/6 |
hematopoietic system homeostasis/metabolism immune system |
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| References |
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Original: |
J:83728
Brinkman-Van Der Linden EC et al.,
"CD33/Siglec-3 Binding Specificity, Expression Pattern, and Consequences of Gene Deletion in Mice."
Mol Cell Biol 2003 Jun;23(12):4199-206
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All: |
1 reference(s)
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