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| Nomenclature |
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Symbol:
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Ppargtm2Rev
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Name:
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peroxisome proliferator activated receptor gamma;
targeted mutation 2, Ronald M Evans
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MGI ID: |
MGI:2651605 |
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Synonyms: |
gf, Ppargflox, PPARgammaf |
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Gene:
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Pparg
Location:
Chr6:115372091-115440419 bp, + strand
Genetic Position: Chr6,
52.7 cM, cytoband E3-F1
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:88210
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: |
Targeted (Floxed/Frt) |
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Mutation: |
Insertion |
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A single loxP site was introduced upstream of exon 1 and a floxed neomycin cassette was inserted downstream of exon 2. The neomycin gene was excised from correctly targeted ES cells by transient transfection with a Cre expression plasmid. (J:88210) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:88210
He W et al.,
"Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle."
Proc Natl Acad Sci U S A 2003 Dec 23;100(26):15712-7
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All: |
12 reference(s)
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