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Rb1tm3Tyj
Targeted Allele Detail

Nomenclature
Symbol: Rb1tm3Tyj
Name: retinoblastoma 1; targeted mutation 3, Tyler Jacks
MGI ID: MGI:2450162
Synonyms: RbloxP, Rb12lox
Gene: Rb1   Location: Chr14:73595309-73725547 bp, - strand    Genetic Position: Chr14, 41.0 cM, cytoband D3
Mutation
origin
Germline Transmission: Earliest citation of germline transmission: J:81643
Parent Cell Line: Not Specified (ES Cell)
Strain of Origin: Not Specified
Mutation
description
Allele Type: Targeted (Floxed/Frt)
Mutation: Insertion
  Single loxP sites flank exon 3. (J:81643)
Find Mice (IMSR) Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation: 32 strains or lines available
Phenotype
summary
help icon
Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
cn1
 
cn2
 
cn3
 
cn4
 
cn5
 
cn6
 
cn7
 
cn8
 
cn9
 
cn10
 
cn11
 
cn12
 
tg13
  
behavior/neurological          		        √    
  
hematopoietic system          		        N    
  
lethality/postnatal          		  √          
  
lethality/prenatal-perinatal          		        √    
  
life span/aging          		   √√ √   √√ 
  
liver/biliary system          		        N    
  
muscle          		        √    
  
nervous system          		    √ √ √√√  
  
reproductive system          		   √      √  
  
respiratory system          		           √ 
  
skin/coat/nails          		√√          √
  
tumorigenesis          		   √√√√   √√ 
  
vision/eye          		  √√√√√√√√√  
 
  
Disease Models          		   √ √√      
Phenotypic
data by
genotype
Phenotypic Data by Genotype

(show or hide all phenotypic details)

GenotypeAllelic CompositionGenetic Background
  
 cn1   		 Rb1tm3Tyj/Rb1tm3Tyj
Tg(KRT14-cre)8Brn/0		 involves: 129 * C57BL/6 * FVB
  
 cn2   		 Rb1tm3Tyj/Rb1tm3Tyj
Tg(KRT14-cre)8Brn/0
Tg(KRT14-HPV16E7)2304Plam/0		 involves: 129 * C57BL/6 * FVB
  
 cn3   		 Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Tg(Nes-cre)1Mrt/0		 involves: 129S2/SvPas
  
 cn4   Disease Model  		 Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm1Tyj/Rbl2tm1Tyj
Tg(Nes-cre)1Mrt/0		 involves: 129S2/SvPas
  
 cn5   		 Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Nes-cre)1Mrt/0		 involves: 129S2/SvPas
  
 cn6   Disease Model  		 Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Tg(Pax6-cre,GFP)2Pgr/0		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N
  
 cn7   Disease Model  		 Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Tg(Pax6-cre,GFP)2Pgr/0		 involves: 129X1/SvJ * C57BL/6 * FVB/N
  
 cn8   		 Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0		 involves: 129X1/SvJ * C57BL/6 * FVB/N
  
 cn9   		 Rb1tm3Tyj/Rb1tm3.1Tyj
Tg(Nes-cre)1Mrt/0		 Not Specified
  
 cn10   		 Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0		 Not Specified
  
 cn11   		 Rb1tm3Tyj/Rb1tm3Tyj
Tg(Nes-cre)1Mrt/0		 Not Specified
  
 cn12   		 Krastm4Tyj/Kras+
Rb1tm3Tyj/Rb1tm3Tyj		 Not Specified
  
 tg13   		 Rb1tm3Tyj/Rb1tm3Tyj
Tg(KRT14-HPV16E7)2304Plam/0		 involves: 129 * C57BL/6 * FVB
Disease
models
Mouse Models
of Human Disease
NoteGenotypeRef(s)
 
Allelic Composition
Genetic Background
Models with phenotypic similarity to human diseases associated with human RB1.
Retinoblastoma; RB1
OMIM ID: 180200		 1
 
cn7		Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Tg(Pax6-cre,GFP)2Pgr/0		involves: 129X1/SvJ * C57BL/6 * FVB/NJ:119919
1
 
cn6		Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Tg(Pax6-cre,GFP)2Pgr/0		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/NJ:119919
1
 
cn4		Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm1Tyj/Rbl2tm1Tyj
Tg(Nes-cre)1Mrt/0		involves: 129S2/SvPasJ:91406
1Conditionally targeted allele(s).
References
Original: J:81643 MacPherson D et al., "Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system." Mol Cell Biol 2003 Feb;23(3):1044-53
All: 17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
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