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A2m Gene Detail
 Symbol
Name
ID
A2m
alpha-2-macroglobulin
MGI:2449119

Nomenclature History
Synonyms A2mp
Genetic Map
Chromosome 6
61.7 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 12)

Sequence Map
Chr6:121586245-121629244 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human A2m ± 2 cM)
Protein SuperFamily: alpha-2-macroglobulin
TreeFam: TF313285
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000030111 Ensembl Gene Model | MGI Sequence Detail 43000 C57BL/6J ± Kb
transcript NM_175628 RefSeq | MGI Sequence Detail 4687 C57BL/6
polypeptide Q6GQT1 UniProt | EBI | MGI Sequence Detail 1474 Not Applicable
For the selected sequences
All sequences(16)
Polymorphisms SNPs within 2kb(430 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process female pregnancy
Component extracellular region, extracellular space...
Function endopeptidase inhibitor activity, peptidase inhibitor activity...
External Resources: FuncBase
Expression cDNA source data(54)
External Resources: GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(54) cDNA(54)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000030111
DoTS DT.97396488
Consensus CDS Project CCDS39617.1
UniGene 30151
DFCI TC1578162
NIA Mouse Gene Index U042766
Entrez Gene 232345
International Mouse Knockout Project Status A2m
Protein
domains
InterPro ID Description
IPR001599 Alpha-2-macroglobulin
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR008930 Terpenoid cylases/protein prenyltransferase alpha-alpha toroid
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 A-macroglobulin complement component
IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
IPR019742 Alpha-2-macroglobulin, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:30080 Hudson NW et al., "Subunit and primary structure of a mouse alpha-macroglobulin, a human alpha 2-macroglobulin homologue." Biochim Biophys Acta 1982 Jun 4;704(2):290-303
(Latest) J:122128 Wielockx B et al., "Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock." J Immunol 2007 Apr 15;178(8):5069-75
All references(19)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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