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| Nomenclature |
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Symbol:
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Hld
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Name:
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hippocampal lamination defect
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MGI ID: |
MGI:2447987 |
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Gene:
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Hld
Location:
unknown
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Mutation
origin |
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Strain of Origin:
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BALB/cJ
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Inheritance: |
Semidominant |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Abnormal laminar organization of the pyramidal layer of the cerebellum, particularly in the proximal segment of the layer, occurs in the BALB/cJ strain (J:5787). A single gene, Hld for hippocampal lamination defect, was shown to cause this abnormality in a cross of BALB/c with C57BL/6 and in the CXB recombinant inbred strains (J:13989).
In normal strains, the latest formed or youngest neurons migrate past the earlier formed or older neurons to a position in the pyramidal layer that is superficial to that of the older cells. In BALB/cJ, the positions are reversed, with the older cells lying superior to the younger ones (J:5787). Since mossy fibers form synapses primarily with the older cells, this aberrant pattern of cell migration in BALB/c leads to a different pattern of mossy-fiber synapses, easily visualized with Timm's stain (J:5486). The dendritic excrescences induced by contact with mossy fibers on late-generated pyramidal cells in +/+ mice occur at sites on both the apical and basal dendrites; in Hld/Hld mice, they occur in two sites on the apical dendrites only (J:12029).
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| References |
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Original: |
J:13989
Nowakowski RS,
"Hippocampal lamination defect = Hld."
Mouse News Lett 1984;71():35
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All: |
5 reference(s)
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