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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm2Dym
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 2, Susan Dymecki
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MGI ID: |
MGI:2447934 |
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Synonyms: |
Gt(ROSA)26Sortm1(ALPP)Dym, R26:FRAP, R26FRAPki |
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Gene:
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Gt(ROSA)26Sor
Location:
unknown
Genetic Position: Chr6,
48.7 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:72406
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: |
Targeted (Reporter) |
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Mutation: |
Insertion |
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An Flp-dependent alkaline phosphatase reporter locus was generated by inserting a construct containing an frt-flanked PGK-neo gene followed by sequence encoding human ALPP. The inserted construct contained a splice acceptor site at the 5' end. In addition to transcriptional and translational stop signals in the frt-flanked region, the frt-flanked neo cassette was inserted immediately downstream of the ALPP start codon to ensure a lack of ALPP activity in the absence of Flp-mediated excision. (J:72406) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
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| References |
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Original: |
J:72406
Awatramani R et al.,
"An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus."
Nat Genet 2001 Nov;29(3):257-9
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All: |
1 reference(s)
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