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| Nomenclature |
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Symbol:
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Tg(Trp53A135V)L3Ber
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Name:
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transgene insertion L3, Alan Bernstein
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MGI ID: |
MGI:2447408 |
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Synonyms: |
p53val135, pL53-3, Tg(pL53)3Ber, Tg(Trp53A135V)2Ber, UL53-3 |
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Transgene:
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Tg(Trp53A135V)L3Ber
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The transgene contains the mouse transformation related protein 53 promoter and an allele of the mouse Trp53 gene that carries a point mutation in codon 135 (GCG to GTG), resulting in an alanine to valine substitution. The Trp53 promoter drove high levels of transgenic expression in the spleen, thymus, and lymph nodes. Transgenic expression was also reported in the ovaries. Little or no expression was reported to have been observed in the liver and lungs of these mice. (J:19870) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
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Tg(Trp53A135V)L3Ber/0 |
involves: C57BL/6 * CD-1 |
life span/aging skin/coat/nails tumorigenesis homeostasis/metabolism skeleton adipose tissue behavior/neurological endocrine/exocrine glands growth/size hematopoietic system immune system liver/biliary system muscle renal/urinary system reproductive system |
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Notes |
Additional lines L1 and L2 were produced.
Homozygous transgenic mice are viable and fertile, but show a high incidence of tumors, particularly lung adenocarcinomas, osteosarcomas, and lymphomas.
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| References |
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Original: |
J:19870
Lavigueur A et al.,
"High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene."
Mol Cell Biol 1989 Sep;9(9):3982-91
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All: |
9 reference(s)
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