Tyr<+> Allele Detail MGI Mouse (MGI:2432472)

Tyr⁺
Allele Detail

Nomenclature

Symbol:	Tyr⁺
Name:	tyrosinase; wild type
MGI ID:	MGI:2432472
Gene:	Tyr Location: Chr7:94577327-94641899 bp, - strand Genetic Position: Chr7, 44.0 cM

Mutation
description

Allele Type:

Not Applicable

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 9 strains available Cell Lines: 0 lines available
Carrying any Tyr Mutation:	206 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	ht1	ht2	cx3
cardiovascular system				√
abnormal vasculogenesis				√
		ht1	ht2	cx3
cellular		√	√
abnormal chromosome morphology		√
chromosome breakage			√
induced chromosome breakage		√	√
		ht1	ht2	cx3
embryogenesis				√
kinked neural tube				√
embryonic growth retardation				√
		ht1	ht2	cx3
growth/size				√
embryonic growth retardation				√
decreased body size				√
		ht1	ht2	cx3
lethality/prenatal-perinatal				√
prenatal lethality				√
		ht1	ht2	cx3
life span/aging				N
life span/aging phenotype				N
		ht1	ht2	cx3
limbs/digits/tail				√
abnormal limb development				√
		ht1	ht2	cx3
nervous system				√
kinked neural tube				√
		ht1	ht2	cx3
skeleton				√
thoracic vertebral fusion				√
abnormal cervical axis morphology				√
lumbar vertebral fusion				√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
ht1	Tyr^c-25H/Tyr⁺	involves: AKR * STOCK Tyr^c-25H/Tyr^c-ch
cellular abnormal chromosome morphology (J:5520) this allele includes a deletion, detected in banded mitotic chromosomes, comprising 1-6cM, representing about 7.6% of Chr 7 induced chromosome breakage (J:5520)
Genotype	Allelic Composition	Genetic Background
ht2	Tyr^c-25H/Tyr⁺	involves: SM/J * STOCK Tyr^c-h/Tyr^c-25H
cellular chromosome breakage (J:5437) induced chromosome breakage (J:5437) an induced, associated deletion involves, minimally, the MOD2 structural locus
Genotype	Allelic Composition	Genetic Background
cx3	Odz4^l7Rn3-4R/Tyr^c-26DVT	Not Specified
lethality/prenatal-perinatal prenatal lethality (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the mother, animals die as embryos between E8.5 and E17.5 life span/aging life span-post-weaning/aging (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the father, animals survive to adulthood cardiovascular system abnormal vasculogenesis (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the mother, defects in vascularization are seen embryogenesis kinked neural tube (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the mother, kinky neural tubes are observed embryonic growth retardation (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the mother, developmental delay is seen growth/size embryonic growth retardation (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the mother, developmental delay is seen decreased body size (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the father, 30% of animals appear runted and scruffy at weaning limbs/digits/tail abnormal limb development (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the mother, abnormalities in limb bud elongation are seen nervous system kinked neural tube (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the mother, kinky neural tubes are observed skeleton thoracic vertebral fusion (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the father, 27% of mutant animals display lumbar and/or thoracic vertebral fusions abnormal cervical axis morphology (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the father, an aberrant spinous process is observed in 18% of mutant animals lumbar vertebral fusion (J:96673) when the Odz4^l7Rn3-4R allele is inherited from the father, 27% of mutant animals display lumbar and/or thoracic vertebral fusions

References

All:	3 reference(s)

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