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| Nomenclature |
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Symbol:
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Mmp12tm1Sds
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Name:
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matrix metallopeptidase 12;
targeted mutation 1, Steven D Shapiro
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MGI ID: |
MGI:2386174 |
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Synonyms: |
MME-, MMP-12-, Mmp12- |
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Gene:
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Mmp12
Location:
Chr9:7344381-7369499 bp, + strand
Genetic Position: Chr9,
1.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:32902
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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The gene was disrupted by replacement of the majority of exon 2 with a PGK-neo cassette via homologous recombination. Gene transcription and protein production was absent in homozygous mutant animals as demonstrated by Northern and Western blot analysis of peritoneal macrophages and peritoneal fluid. (J:32902) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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1One or more human genes may be associated with the human disease. The mouse genotype may involve mutations in orthologous genes, but the phenotype did not resemble the human disease.
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| References |
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Original: |
J:32902
Shipley JM et al.,
"Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice."
Proc Natl Acad Sci U S A 1996 Apr 30;93(9):3942-6
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All: |
32 reference(s)
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