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| Nomenclature |
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Symbol:
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Tg(Prnp-MAPT)43Vle
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Name:
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transgene insertion 43, Virginia M Y Lee
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MGI ID: |
MGI:2385566 |
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Transgene:
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Tg(Prnp-MAPT)43Vle
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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A transgenic construct containing a cDNA sequence to human MAPT (fetal tau, Tau44 isoform) under the control of the mouse Prnp promtoer was used to create transgenic animals. Quantitative Western blot analysis showed hyperphosphorylated, insoluble MAPT protein to be widely expressed in neurons of the CNS at levels approximately 10 fold higher than the endogenous mouse counterpart. (J:61052) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
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Tg(Prnp-MAPT)43Vle/Tg(Prnp-MAPT)43Vle |
involves: C57BL/6 * DBA/2 |
lethality/prenatal-perinatal life span/aging |
| Genotype | Allelic Composition | Genetic Background |
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tg2
Disease Model |
Tg(Prnp-MAPT)43Vle/0 |
involves: C57BL/6 * DBA/2 |
nervous system behavior/neurological growth/size 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Notes |
Three founder lines were generated - lines 7, 27 and 43. Hemizygous mice from line 27 are not viable beyond 3 months and were not characterized in J:61052. Hemizygous mice from line 7 are phenotypically similar to line 43, however inclusions in the spinal cord are smaller and less abundant than in line 43.
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| References |
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Original: |
J:61052
Ishihara T et al.,
"Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform."
Neuron 1999 Nov;24(3):751-62
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All: |
3 reference(s)
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