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Tg(TRAMP)8247Ng
Transgene Detail

Nomenclature
Symbol: Tg(TRAMP)8247Ng
Name: transgene insertion 8247, Norman M Greenberg
MGI ID: MGI:2384595
Synonyms: TRAMP
Transgene: Tg(TRAMP)8247Ng   Location: unknown    
Histological analysis of prostate tumors in Tg(TRAMP)8247Ng/0 mice

Show the 1 image(s) involving this allele.

Transgene
origin
Strain of Origin: C57BL/6
Transgene
description
Transgene Type: Transgenic (random, expressed)
Mutation: Insertion
  Expression of the SV40 early region tumor antigen was driven in mouse prostrate epithelium via a rat probasin promoter region fragment (-426/+28 bp). (J:65303, J:73560)
Find Mice (IMSR) Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
tg1
 
tg2
 
tg3
 
tg4
 
tg5
 
tg6
 
tg7
 
tg8
 
tg9
 
tg10
 
tg11
 
tg12
 
tg13
 
tg14
 
tg15
 
tg16
 
tg17
 
tg18
  
cellular          		              √   
  
endocrine/exocrine glands          		  √√              
  
life span/aging          		      √           
  
reproductive system          		  √√              
  
tumorigenesis          		√√√√√√√√√√√√√√√√√√
 
  
Disease Models          		   √     √√√  √  √
Phenotypic
data by
genotype
Phenotypic Data by Genotype

(show or hide all phenotypic details)

GenotypeAllelic CompositionGenetic Background
  
 tg1   		 Tg(TRAMP)8247Ng/0 involves: 129/Sv * C57BL/6
  
 tg2   		 Tg(TRAMP)8247Ng/0 involves: 129S1/Sv * C57BL/6
  
 tg3   		 Tg(TRAMP)8247Ng/0 involves: C3H * C57BL/6
  
 tg4   Disease Model  images  		 Tg(TRAMP)8247Ng/0 involves: C57BL/6
  
 tg5   		 Ahrtm1Bra/Ahrtm1Bra
Tg(TRAMP)8247Ng/0		 B6.Cg-Ahrtm1Bra Tg(TRAMP)8247Ng
  
 tg6   		 Ahrtm1Bra/Ahr+
Tg(TRAMP)8247Ng/0		 B6.Cg-Ahrtm1Bra Tg(TRAMP)8247Ng
  
 tg7   		 Tg(Tcra,Tcrb)HRVAll/0
Tg(TRAMP)8247Ng/0		 B6.Cg-Tg(Tcra,Tcrb)HRVAll Tg(TRAMP)8247Ng
  
 tg8   		 Pscatm1Witt/Pscatm1Witt
Tg(TRAMP)8247Ng/0		 involves: 129/Sv * C57BL/6
  
 tg9   		 Pscatm1Witt/Psca+
Tg(TRAMP)8247Ng/0		 involves: 129/Sv * C57BL/6
  
 tg10   Disease Model  		 Artm1(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		 involves: 129S1/Sv * C57BL/6
  
 tg11   Disease Model  		 Artm2(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		 involves: 129S1/Sv * C57BL/6
  
 tg12   Disease Model  		 Artm3(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		 involves: 129S1/Sv * C57BL/6
  
 tg13   		 Il8rbtm1Mwm/Il8rbtm1Mwm
Tg(TRAMP)8247Ng/?		 involves: 129S2/SvPas * BALB/c * C57BL/6
  
 tg14   		 Tbx21tm1Glm/Tbx21tm1Glm
Tg(TRAMP)8247Ng/0		 involves: 129S6/SvEvTac * C57BL/6
  
 tg15   Disease Model  		 Tg(CAG-SAC/EGFP)35Rang/0
Tg(TRAMP)8247Ng/0		 involves: C3H * C57BL/6
  
 tg16   		 Cxcr3tm1Wwh/Cxcr3tm1Wwh
Tg(TRAMP)8247Ng/?		 involves: C57BL/6
  
 tg17   		 Klrk1tm1Dhr/Klrk1tm1Dhr
Tg(TRAMP)8247Ng/?		 involves: C57BL/6 * CD-1
  
 tg18   Disease Model  		 Tg(Pbsn-IGF1*)5305Ng/0
Tg(TRAMP)8247Ng/0		 involves: C57BL/6 * FVB/N
Disease
models
Mouse Models
of Human Disease
NoteGenotypeRef(s)
 
Allelic Composition
Genetic Background
Models involving transgenes or other mutation types.1
Prostate Cancer
OMIM ID: 176807		  
 
tg10		Artm1(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		involves: 129S1/Sv * C57BL/6J:108849
 
 
tg11		Artm2(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		involves: 129S1/Sv * C57BL/6J:108849
 
 
tg12		Artm3(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		involves: 129S1/Sv * C57BL/6J:108849
 
 
tg15		Tg(CAG-SAC/EGFP)35Rang/0
Tg(TRAMP)8247Ng/0		involves: C3H * C57BL/6J:125633
 
 
tg18		Tg(Pbsn-IGF1*)5305Ng/0
Tg(TRAMP)8247Ng/0		involves: C57BL/6 * FVB/NJ:144539
 
 
tg4		Tg(TRAMP)8247Ng/0involves: C57BL/6J:65303
1Models involving transgenes or other mutation types may also appear in other sections of the table.
Notes TRAMP stands for TRansgenic Adenocarcinoma Mouse Prostate. Lines 5666 and 8079 were also produced.

Transgenic mice on a C57BL6 background develop progressive forms of prostate cancer with distant site metastasis. Forms of disease range from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. Tumors are detected in the prostate as early as 10 weeks of age. The tumors have elevated levels of nuclear TRP53 and decreased androgen receptor expression.

References
Original: J:65303 Greenberg NM et al., "Prostate cancer in a transgenic mouse." Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3439-43
All: 145 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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11/20/2009
MGI_4.31
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