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| Nomenclature |
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Symbol:
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Tg(SOD1*G93A)1Gur
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Name:
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transgene insertion 1, Mark E Gurney
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MGI ID: |
MGI:2183719 |
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Synonyms: |
(G93A)Tg+, G1H, G93A, G93A SOD1, G93A+, G93A-SOD1, hSOD1G93A, SOD1 G93A, SOD1 Tg, SOD1G93A, Tg(G93A-SOD1)1Gur, Tg(SOD1-G93A)1Gur, TgN(SOD1-G93A)1Gur, TgN[SOD1-G93A]1Gur |
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Transgene:
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Tg(SOD1*G93A)1Gur
Location:
unknown
Genetic Position: Chr12,
cytoband E
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Presence of neurofilament spheroids in the spinal cord of an 82-day old Tg(SOD1)2Gur mouse
Show the 3 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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This transgenic subline (designated G1H in J:76718) is derived from the G1 parental transgenic line (originally described in J:32665). This line carries a 40% expansion in transgene copy number compared to the original G1 line (described in J:32665, in MGI as Tg(SOD1*G93A)2Gur). The transgene construct is composed of the human SOD1 gene carrying a glycine to alanine transition at position 93 (G93A). The G93A mutation does not alter the activity of the protein. This line carries a high copy number. (J:32665, J:76718) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
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(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
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expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Notes |
This line, G1H, was derived from the original G1 line (now designated Tg(SOD1*G93A)2Gur) reported in J:32665. Transgenic mice on a background that involves C57BL/6 and SJL express high levels of the transgene with a 4-fold increase in SOD activity, and exhibit a phenotype similar to amyotrophic lateral sclerosis (ALS) in humans. Hemizygous transgenic mice become paralyzed in one or more limbs and have a life span of approximately 19-23 weeks. Paralysis is due to loss of motor neurons from the spinal cord.
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| References |
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Original: |
J:32665
Gurney ME et al.,
"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]"
Science 1994 Jun 17;264(5166):1772-5
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All: |
209 reference(s)
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