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| Nomenclature |
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Symbol:
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Lta4htm1Bhk
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Name:
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leukotriene A4 hydrolase;
targeted mutation 1, Beverly H Koller
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MGI ID: |
MGI:2182082 |
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Synonyms: |
LtA4 hydrolase- |
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Gene:
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Lta4h
Location:
Chr10:92916156-92947619 bp, + strand
Genetic Position: Chr10,
cytoband C3
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:58985
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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A neomycin selection cassette replaced 114 base pairs of coding sequence. Northern blot analysis of total RNA showed an absence of transcript in bone marrow and bone marrow mast cells, both obtained from homozygous mutant mice. (J:58985) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:58985
Byrum RS et al.,
"Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice."
J Immunol 1999 Dec 15;163(12):6810-9
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All: |
4 reference(s)
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