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| Nomenclature |
|
Symbol:
|
Clutm1Jakh
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|
Name:
|
clusterin;
targeted mutation 1, Judith A K Harmony
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MGI ID: |
MGI:2181011 |
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Gene:
|
Clu
Location:
Chr14:66587320-66600385 bp, + strand
Genetic Position: Chr14,
28.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:65660
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
|
Mutations: |
Insertion, Intragenic deletion |
| |
An HPRT cassette replaced exons 1 and 2. Normal transcript was undetectable in homozygous mutant tissue. Western blot analysis of plasma and liver extracts showed an absence of protein in homozygous mutant mice. (J:2892, J:65660, J:67960) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
|
| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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|
Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
|
1Models involving transgenes or other mutation types may also appear in other sections of the table.
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| References |
|
Original: |
J:65660
McLaughlin L et al.,
"Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis"
J Clin Invest 2000 Nov;106(9):1105-13
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All: |
18 reference(s)
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