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| Nomenclature |
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Symbol:
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Cd22tm1Lam
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Name:
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CD22 antigen;
targeted mutation 1, Marinus C Lamers
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MGI ID: |
MGI:2180698 |
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Synonyms: |
CD22- |
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Gene:
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Cd22
Location:
Chr7:31650848-31665361 bp, - strand
Genetic Position: Chr7,
9.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:38644
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Parent Cell Line:
| BL/6-III (ES Cell) |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutation: |
Insertion |
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Exon 11, encoding the transmembrane domain, was disrupted by the insertion of a neomycin cassette. Flow cytometric analysis showed an absence of surface expression on splenocytes isolated from homozygous mutant mice. (J:38644) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:38644
Nitschke L et al.,
"CD22 is a negative regulator of B-cell receptor signalling."
Curr Biol 1997 Feb 1;7(2):133-43
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All: |
13 reference(s)
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