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| Nomenclature |
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Symbol:
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Selplgtm1Rpmc
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Name:
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selectin, platelet (p-selectin) ligand;
targeted mutation 1, Rodger P McEver
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MGI ID: |
MGI:2180375 |
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Synonyms: |
PSGL-1- |
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Gene:
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Selplg
Location:
Chr5:114268561-114280442 bp, - strand
Genetic Position: Chr5,
64.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:75829
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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A neomycin resistance cassette replaced the 5' portion of exon 2, which includes the translation initiation start site, via homologous recombination. Flow cytometry was used to confirm the absence of gene expression in leukocytes of homozygous mutant animals. (J:75829, J:95268) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:75829
Xia L et al.,
"P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow."
J Clin Invest 2002 Apr;109(7):939-50
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All: |
9 reference(s)
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